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Test E, Deca, DBOL Cycle AUSTRALIAN BODYBUILDING & FITNESS FORUM

Overview of Testosterone Enanthate Dosing

The following guide summarises the commonly discussed dosage levels for Testosterone Enanthate (a long‑acting injectable testosterone ester) that appear in online forums and support‑group discussions.

> Important: This information is purely educational. It does not replace professional medical advice. Always consult a qualified healthcare provider before initiating, adjusting, or discontinuing any hormone therapy.

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1. Commonly Mentioned Dose Ranges

Category Typical Dose (mg) Frequency of Administration Approximate Duration of Effect

Baseline/Replacement 100–200 mg per week Once weekly (or every 2 weeks at the higher end) 4–6 weeks

Therapeutic/Bodybuilding 200–400 mg per week Weekly or split dosing (e.g., two injections of 150 mg each) 3–5 weeks

High-Intensity Protocols > 400 mg per week Twice weekly or more frequent 1–2 weeks

> Key point: The total weekly dose is the most important determinant of systemic effects, not the individual injection size. Splitting a high dose into multiple injections can reduce peak plasma concentration but does not change the overall exposure.

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How the Body Processes Testosterone

Absorption

Phase Details

Injection Intramuscular depot (e.g., testosterone enanthate) releases oil‑soluble ester into muscle tissue.

Diffusion Ester slowly diffuses into interstitial fluid and then into capillaries.

Peak Concentration (Cmax) Occurs ~24–48 h after injection, depending on the specific ester.

Metabolism

Enzyme Hydrolysis

- Testosterone esterase in blood and tissues cleaves the ester group → free testosterone + fatty acid.

Oxidation / Reductive Pathways

- CYP3A4 (liver) converts testosterone to 6β-hydroxytestosterone.

- AKR1C3 reduces androstenedione to testosterone; AKR1C2/5 convert testosterone → 5α-dihydrotestosterone (DHT).

Conjugation

- UDP-glucuronosyltransferases (UGTs) attach glucuronic acid → testosterone‑glucuronide.

- Sulfotransferases (SULTs) add sulfate groups → testosterone‑sulfate.

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2. Metabolic Pathways

Step Reaction Key Enzymes & Proteins

1 Activation of cholesterol to pregnenolone CYP11A1 (P450SCC) – mitochondrial; CYP27A1 also contributes.

2 Pregnenolone → Progesterone 3β‑HSD (HSD3B1/2) – cytosolic, membrane‑bound.

3 Progesterone → Pregnenolone 5α‑Reductase type 1/2 (SRD5A1/2).

4 Pregnenolone → Progesterone (reverse) 3β‑HSD (again).

5 Progesterone → 17α‑Hydroxyprogesterone CYP17A1 (17α‑hydroxylase).

6 17α‑Hydroxyprogesterone → Dehydroepiandrosterone (DHEA) CYP17A1 (17,20‑lyase).

7 Dehydroepiandrosterone (DHEA) → Androstenedione HSD3B2.

8 Androstenedione → Testosterone HSD17B3 or 17β‑hydroxysteroid dehydrogenase type 5.

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4. Enzymes that Regulate Steroid Hormone Production

Cytochrome P450scc (CYP11A1) – converts cholesterol to pregnenolone (first step in all steroidogenesis).

17α‑Hydroxylase/17,20‑lyase (CYP17A1) – essential for glucocorticoid and androgen synthesis; dual activity: 17α‑hydroxylation of pregnenolone/corticosterone to form dehydroepiandrosterone (DHEA) & androstenedione.

21‑Hydroxylase (CYP21A2) – converts progesterone & 17‑OHP to 11-deoxycortisol and corticosterone, respectively.

24‑Hydroxylase (CYP24A1) – catabolic enzyme for 1α,25‑dihydroxyvitamin D3; it also degrades 7‑dehydrocholesterol to 7‑hydroxyderivatives.

27‑Hydroxylase (CYP27B1) – the key vitamin D3 activating enzyme that converts 25‑OH‑D3 to 1α,25‑(OH)₂‑D₃; it also hydroxylates cholesterol derivatives in bile acid synthesis.

These enzymes illustrate the broad functional diversity of the CYP24A1 and CYP27B1 families beyond classical steroid metabolism.
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