KPV peptide is a short synthetic fragment derived from the larger protein alpha-1-antitrypsin, and it has attracted scientific interest for its anti-inflammatory properties in various disease models. If you are looking to purchase KPV peptide for research or therapeutic development, there are several key aspects that will help guide your decision—from understanding why this peptide is valuable, through exploring the range of products available, to appreciating its chemical structure and synthesis details.
Buy KPV Peptide
When deciding to buy KPV peptide, it is essential first to verify that the vendor offers a product that meets your purity, quality, and specification requirements. A reputable supplier should provide certificates of analysis confirming high purity (typically ≥95 %), absence of endotoxin contamination, and accurate mass determination through techniques such as MALDI-TOF or ESI-MS. Many companies also offer custom synthesis options, allowing you to request specific isotopic labels or modifications that can be useful for mechanistic studies.
The purchasing process usually involves selecting the desired scale—ranging from microgram quantities for in-vitro assays up to gram‐scale batches for preclinical studies. Shipping conditions are important; peptides often require cold chain logistics and should arrive within a temperature window of 2–8 °C to preserve stability. After receiving your shipment, it is good practice to perform an independent quality check, such as HPLC profiling or SDS-PAGE analysis if the peptide is prone to aggregation.
Shop our Full Range of KPV Peptides
Our full range of KPV peptides includes not only the standard linear sequence but also several derivatives that may enhance solubility or biological activity. Some options available are:
Unmodified Linear KPV – The canonical 3-residue peptide (Lys-Pro-Val) that has been shown to inhibit neutrophil migration and reduce cytokine production in inflammatory models.
PEGylated KPV – Conjugation with polyethylene glycol improves half-life in vivo, making it suitable for systemic administration studies.
D-Amino Acid Substituted KPV – Replacing L-residues with their D-enantiomers can increase resistance to proteolytic degradation without significantly altering activity.
Fluorescently Tagged KPV – Incorporation of a fluorophore at the N-terminus allows tracking of peptide distribution in cell culture or animal models.
Cyclized KPV Peptide – Cyclization between the terminal residues can stabilize the conformation and reduce aggregation.
Each product variant comes with detailed documentation, including recommended storage conditions (usually −20 °C for long-term), solubility data in aqueous buffers, and suggested concentrations for typical experimental protocols. If you are planning a specific application—such as an anti-inflammatory assay or a delivery study—the supplier can help match the appropriate peptide form to your needs.
Structure of KPV Peptide
The core structure of KPV is remarkably simple yet functionally potent. Chemically, it consists of three amino acids arranged in a linear chain: Lysine (Lys), Proline (Pro), and Valine (Val). The sequence can be represented as Lys-Pro-Val, where the N-terminus is free or capped depending on synthesis strategy. Because the peptide contains only one positively charged residue (lysine) and two hydrophobic residues (proline and valine), it displays a balanced amphipathic character that facilitates interaction with cell membranes and inflammatory mediators.
From a structural biology perspective, proline introduces a rigid kink in the backbone due to its cyclic side chain. This kink can promote a specific conformation that is recognized by receptors or enzymes involved in inflammation pathways. The lysine residue provides a site for potential post-synthetic modifications such as acetylation or amidation, which may modulate peptide stability or receptor binding.
In solution, KPV typically adopts an extended conformation but can form transient secondary structures when interacting with lipid bilayers or protein partners. High-resolution techniques like NMR spectroscopy have revealed that the peptide’s backbone is flexible yet retains a defined orientation of the side chains, especially in the presence of hydrophobic environments. Understanding this structure–function relationship helps researchers design analogues with improved potency or pharmacokinetics.
When synthesizing KPV, solid-phase peptide synthesis (SPPS) is the standard approach. The Fmoc strategy allows for stepwise addition of protected amino acids on a resin, followed by cleavage and purification via reverse-phase HPLC. For high-throughput studies, automated synthesizers can produce multiple batches quickly, ensuring consistent quality across experiments.
In summary, buying KPV peptide involves selecting a trustworthy supplier that provides rigorous purity data, choosing the right variant for your application from our comprehensive catalog, and appreciating the concise yet biologically significant structure of the Lys-Pro-Val sequence. With these considerations in mind, researchers can effectively incorporate KPV into their studies on inflammation, immune modulation, or drug delivery systems.